Deep brain stimulation and cognitive functions in Parkinson's disease: A three‐year controlled study
Identifieur interne : 002368 ( Main/Exploration ); précédent : 002367; suivant : 002369Deep brain stimulation and cognitive functions in Parkinson's disease: A three‐year controlled study
Auteurs : Roberta Zangaglia [Italie] ; Claudio Pacchetti [Italie] ; Chiara Pasotti [Italie] ; Francesca Mancini [Italie] ; Domenico Servello [Italie] ; Elena Sinforiani [Italie] ; Silvano Cristina [Italie] ; Marco Sassi [Italie] ; Giuseppe Nappi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Cognition (drug effects), Cognition (physiology), Cognition Disorders (etiology), Cognition Disorders (therapy), Combined Modality Therapy, Deep Brain Stimulation, Deep brain stimulation, Disease Progression, Executive Function (drug effects), Executive Function (physiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Prospective Studies, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Speech Disorders (etiology), Speech Disorders (therapy), Subthalamic Nucleus (physiology), Subthalamic nucleus, cognitive functions, deep brain stimulation, subthalamic nucleus.
- MESH :
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- drug effects : Cognition, Executive Function, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- etiology : Cognition Disorders, Speech Disorders.
- physiology : Cognition, Executive Function, Psychomotor Performance, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Cognition Disorders, Parkinson Disease, Speech Disorders.
- Aged, Combined Modality Therapy, Deep Brain Stimulation, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies.
Abstract
There is debate over the cognitive and behavioral effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease (PD). To evaluate these effects, we performed a prospective, naturalistic controlled, 3‐year follow‐up study. A total of 65 PD patients were enrolled, of whom 32 underwent STN‐DBS (PD‐DBS) and 33, even though eligible for this treatment, declined surgery and chose other therapeutic procedures (PD‐control). Motor and neuropsychological functions were assessed in all the subjects at baseline (T0) and 36 months (T36). The PD‐DBS patients were also evaluated at 1, 6, 12, and 24 months after surgery (T1, T6, T12, and T24). At T1, compared with T0, the PD‐DBS patients recorded worse logical executive function task and verbal fluency (FAS) scores, whereas their performance of memory tasks remained stable. At T12, their cognitive profile had returned within the pre‐DBS range, thereafter remaining stable until T36. FAS scores at T36 were significantly worse in the PD‐DBS compared with the PD‐control patients. This is the first long‐term naturalistic controlled study of cognitive functions in PD patients submitted to STN‐DBS. Our results confirm previous reports of a worsening of verbal fluency after DBS, but show that STN‐DBS seems to be relatively safe from a cognitive standpoint, as the short‐term worsening of frontal‐executive functions was found to be transient. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22603
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1621">1621</biblScope><biblScope unit="page" to="1628">1628</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7886878906916ED61FB029A407A8BC1D64A5936E</idno><idno type="DOI">10.1002/mds.22603</idno><idno type="ArticleID">MDS22603</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cognition (drug effects)</term><term>Cognition (physiology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (therapy)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Deep brain stimulation</term><term>Disease Progression</term><term>Executive Function (drug effects)</term><term>Executive Function (physiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prospective Studies</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Speech Disorders (etiology)</term><term>Speech Disorders (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>cognitive functions</term><term>deep brain stimulation</term><term>subthalamic nucleus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term><term>Executive Function</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Speech Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Executive Function</term><term>Psychomotor Performance</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term><term>Speech Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Noyau sousthalamique</term><term>Pathologie du système nerveux</term><term>Stimulation cérébrale profonde</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is debate over the cognitive and behavioral effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease (PD). To evaluate these effects, we performed a prospective, naturalistic controlled, 3‐year follow‐up study. A total of 65 PD patients were enrolled, of whom 32 underwent STN‐DBS (PD‐DBS) and 33, even though eligible for this treatment, declined surgery and chose other therapeutic procedures (PD‐control). Motor and neuropsychological functions were assessed in all the subjects at baseline (T0) and 36 months (T36). The PD‐DBS patients were also evaluated at 1, 6, 12, and 24 months after surgery (T1, T6, T12, and T24). At T1, compared with T0, the PD‐DBS patients recorded worse logical executive function task and verbal fluency (FAS) scores, whereas their performance of memory tasks remained stable. At T12, their cognitive profile had returned within the pre‐DBS range, thereafter remaining stable until T36. FAS scores at T36 were significantly worse in the PD‐DBS compared with the PD‐control patients. This is the first long‐term naturalistic controlled study of cognitive functions in PD patients submitted to STN‐DBS. Our results confirm previous reports of a worsening of verbal fluency after DBS, but show that STN‐DBS seems to be relatively safe from a cognitive standpoint, as the short‐term worsening of frontal‐executive functions was found to be transient. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name></noRegion><name sortKey="Cristina, Silvano" sort="Cristina, Silvano" uniqKey="Cristina S" first="Silvano" last="Cristina">Silvano Cristina</name><name sortKey="Cristina, Silvano" sort="Cristina, Silvano" uniqKey="Cristina S" first="Silvano" last="Cristina">Silvano Cristina</name><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name><name sortKey="Nappi, Giuseppe" sort="Nappi, Giuseppe" uniqKey="Nappi G" first="Giuseppe" last="Nappi">Giuseppe Nappi</name><name sortKey="Nappi, Giuseppe" sort="Nappi, Giuseppe" uniqKey="Nappi G" first="Giuseppe" last="Nappi">Giuseppe Nappi</name><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><name sortKey="Pasotti, Chiara" sort="Pasotti, Chiara" uniqKey="Pasotti C" first="Chiara" last="Pasotti">Chiara Pasotti</name><name sortKey="Pasotti, Chiara" sort="Pasotti, Chiara" uniqKey="Pasotti C" first="Chiara" last="Pasotti">Chiara Pasotti</name><name sortKey="Sassi, Marco" sort="Sassi, Marco" uniqKey="Sassi M" first="Marco" last="Sassi">Marco Sassi</name><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name><name sortKey="Sinforiani, Elena" sort="Sinforiani, Elena" uniqKey="Sinforiani E" first="Elena" last="Sinforiani">Elena Sinforiani</name><name sortKey="Sinforiani, Elena" sort="Sinforiani, Elena" uniqKey="Sinforiani E" first="Elena" last="Sinforiani">Elena Sinforiani</name><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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